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Charis Eng Selected Research

Multiple Hamartoma Syndrome (Cowden's Disease)

10/2022A randomized controlled trial of everolimus for neurocognitive symptoms in PTEN hamartoma tumor syndrome.
11/2020Germline PTEN mutations are associated with a skewed peripheral immune repertoire in humans and mice.
1/2020PTEN in Hereditary and Sporadic Cancer.
1/2020WWP1 Gain-of-Function Inactivation of PTEN in Cancer Predisposition.
4/2019Dynamics and structural stability effects of germline PTEN mutations associated with cancer versus autism phenotypes.
1/2017Cowden syndrome-associated germline succinate dehydrogenase complex subunit D (SDHD) variants cause PTEN-mediated down-regulation of autophagy in thyroid cancer cells.
1/2017Immune dysregulation in patients with PTEN hamartoma tumor syndrome: Analysis of FOXP3 regulatory T cells.
12/2015ACG Guidelines on Management of PTEN-Hamartoma Tumor Syndrome: Does the Evidence Support so Much so Young?
7/2015Balancing Proliferation and Connectivity in PTEN-associated Autism Spectrum Disorder.
3/2015Germline PTEN, SDHB-D, and KLLN alterations in endometrial cancer patients with Cowden and Cowden-like syndromes: an international, multicenter, prospective study.
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Charis Eng Research Topics

Disease

129Neoplasms (Cancer)
10/2022 - 05/2002
39Breast Neoplasms (Breast Cancer)
01/2022 - 07/2002
34Multiple Hamartoma Syndrome (Cowden's Disease)
10/2022 - 06/2002
20Thyroid Neoplasms (Thyroid Cancer)
01/2022 - 09/2002
17Carcinogenesis
01/2020 - 06/2002
12Paraganglioma (Paragangliomas)
01/2021 - 10/2002
9Squamous Cell Carcinoma of Head and Neck
06/2017 - 01/2007
9Carcinoma (Carcinomatosis)
03/2013 - 09/2002
8Pheochromocytoma
01/2019 - 05/2002
6Multiple Endocrine Neoplasia Type 2a (MEN 2)
05/2014 - 05/2002
6Colorectal Neoplasms (Colorectal Cancer)
04/2013 - 08/2002
6Adenoma (Adenomas)
09/2006 - 09/2002
5COVID-19
01/2022 - 01/2020
5Ovarian Neoplasms (Ovarian Cancer)
01/2020 - 10/2007
5Megalencephaly
10/2019 - 12/2012
5Follicular Adenocarcinoma
09/2006 - 05/2003
4Autistic Disorder (Autism)
06/2021 - 05/2013
4Prostatic Neoplasms (Prostate Cancer)
08/2014 - 06/2006
4von Hippel-Lindau Disease (von Hippel Lindau Disease)
06/2012 - 05/2002
4Melanoma (Melanoma, Malignant)
08/2009 - 05/2002
3Neurodevelopmental Disorders
10/2022 - 02/2014
3Colonic Neoplasms (Colon Cancer)
01/2021 - 10/2002
3Inflammation (Inflammations)
01/2021 - 04/2012
3Autism Spectrum Disorder
11/2020 - 02/2014
3Adenocarcinoma
04/2015 - 12/2006
3Microsatellite Instability
07/2013 - 04/2008
3Neoplasm Metastasis (Metastasis)
03/2013 - 06/2009
3Cowden-Like Syndrome
11/2012 - 12/2010
3Uveal melanoma
01/2011 - 01/2005
3Papillary Thyroid Cancer
02/2005 - 05/2003
2Metabolic Syndrome (Dysmetabolic Syndrome X)
10/2022 - 01/2018
2Fallopian Tube Neoplasms
01/2022 - 07/2006
2Hamartoma
01/2022 - 03/2010
2Epilepsy (Aura)
01/2021 - 01/2019
2Infertility (Sterility)
01/2021 - 03/2011
2Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
11/2020 - 07/2020
2Crohn Disease (Crohn's Disease)
11/2020 - 07/2020
2Glioblastoma (Glioblastoma Multiforme)
11/2019 - 01/2019
2Genomic Instability
01/2018 - 01/2016
2Hyperplasia
01/2017 - 08/2004
2Endometrial Neoplasms (Endometrial Cancer)
09/2015 - 07/2013
2Anaplastic Thyroid Carcinoma
07/2014 - 06/2003
2follicular Thyroid cancer
07/2014 - 02/2005

Drug/Important Bio-Agent (IBA)

44Phosphoric Monoester Hydrolases (Phosphatases)IBA
01/2022 - 06/2002
34TensinsIBA
01/2022 - 11/2002
27DNA (Deoxyribonucleic Acid)IBA
01/2021 - 07/2002
22Proteins (Proteins, Gene)FDA Link
05/2021 - 05/2002
19PTEN Phosphohydrolase (PTEN Phosphatase)IBA
03/2015 - 05/2002
15Succinate Dehydrogenase (Fumarate Reductase)IBA
10/2019 - 05/2002
11LipidsIBA
05/2021 - 06/2002
10Biological ProductsIBA
01/2022 - 01/2006
9Biomarkers (Surrogate Marker)IBA
01/2021 - 11/2006
9Transcription Factors (Transcription Factor)IBA
01/2019 - 07/2002
9RacivirIBA
07/2014 - 05/2003
7Pharmaceutical PreparationsIBA
11/2020 - 02/2012
6RNA (Ribonucleic Acid)IBA
01/2022 - 07/2020
6PPAR gammaIBA
04/2008 - 10/2002
5Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
01/2020 - 11/2009
4Transforming Growth Factor beta (TGF-beta)IBA
01/2022 - 10/2003
4Phosphatidylinositols (Phosphatidylinositol)IBA
05/2021 - 07/2002
4TOR Serine-Threonine KinasesIBA
01/2021 - 11/2009
4LigandsIBA
01/2021 - 10/2002
4Phosphotransferases (Kinase)IBA
08/2019 - 08/2003
4Messenger RNA (mRNA)IBA
04/2015 - 09/2002
4Androgen Receptors (Androgen Receptor)IBA
02/2014 - 11/2010
4AndrogensIBA
06/2013 - 11/2010
3Sirolimus (Rapamycin)FDA Link
10/2022 - 06/2010
3CatecholaminesIBA
01/2021 - 11/2004
3Therapeutic UsesIBA
01/2021 - 02/2014
3Hormones (Hormone)IBA
05/2017 - 08/2006
3TamoxifenFDA LinkGeneric
05/2017 - 07/2014
3Calcibiotic Root Canal SealerIBA
04/2013 - 08/2002
3Adenosine Triphosphate (ATP)IBA
01/2011 - 09/2008
2EverolimusFDA Link
10/2022 - 03/2021
2AdiponectinIBA
10/2022 - 01/2007
2Brain-Derived Neurotrophic Factor (BDNF)IBA
01/2021 - 01/2019
2Apolipoproteins E (ApoE)IBA
01/2021 - 01/2019
216S Ribosomal RNAIBA
01/2021 - 04/2012
2Immune Checkpoint InhibitorsIBA
10/2020 - 01/2019
2Lactic Acid (Lactate)FDA LinkGeneric
10/2019 - 06/2017
2Calcitonin (Calcitonin, Eel)FDA LinkGeneric
01/2019 - 04/2015
2SteroidsIBA
01/2019 - 05/2014
2Estrogens (Estrogen)FDA Link
10/2017 - 02/2009
2Phosphates (Orthophosphate)IBA
06/2017 - 11/2002
2Estrogen ReceptorsIBA
05/2017 - 05/2007
2Oral ContraceptivesIBA
09/2015 - 02/2014
2Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA
07/2015 - 06/2002

Therapy/Procedure

24Therapeutics
10/2022 - 10/2002
8Ovariectomy (Oophorectomy)
01/2022 - 07/2006
5Thyroidectomy
01/2022 - 06/2009
4Genomic Medicine
11/2008 - 08/2005
3Immunotherapy
10/2020 - 05/2017
2Salpingo-oophorectomy
01/2020 - 07/2006
2Adrenalectomy
01/2019 - 05/2014
2Precision Medicine
01/2018 - 01/2016
2Oral Hygiene (Dental Hygiene)
11/2017 - 04/2012
2Mastectomy (Mammectomy)
10/2017 - 01/2017
2Hormone Replacement Therapy (Therapy, Hormone Replacement)
01/2016 - 09/2015
2Prostatectomy (Retropubic Prostatectomy)
08/2014 - 03/2013
2Prophylactic Mastectomy
06/2014 - 11/2013